Neuromuscular Pharmacology DEMO

Experiment 1a - Intravenous (IV) Injection Decamethonium


After establishing a control response 0.02 mg/kg of DECAMETHONIUM is injected intravenously.


Describe the change in twitch tension immediately following injection but before appearance of the block.

Tubocurarine causes a reversible decrease in twitch tension
Decamethonium produces an initial increase in twitch tension followed by a reversible decrease
Tubocurarine produces a peak fall in twitch tension of about 75%
The pattern of the response to decamethonium is the same as that for tubocurarine