Rat Blood Pressure DEMO

Isoprenaline is a synthetic drug with an isopropyl- group on the nitrogen of noradrenaline. Heart rate and force are increased through beta₁ -adrenoceptors (G-protein coupled to adenylate cyclase). Beta₂ -adrenoceptors dilate resistance vessels in e.g. muscle and reduce total peripheral resistance; diastolic pressure falls therefore. Alpha₁ -adrenoceptors are little affected therefore arteriolar constriction is not seen and systolic pressure does not increase.