Guinea Pig Ileum DEMO

Introduction


This program simulates an isolated preparation of the guinea pig ileum, a smooth muscle preparation exhibiting little spontaneous contractile activity, which is extensively used for pharmacological studies. Although the program is versatile and may be useful for a variety of student audiences it is primarily intended to be used by undergraduates studying courses in which pharmacology is a major component. Its aim is to enable the exploration of the effects of drugs on the release of and response to neurotransmitters in the enteric nervous system. Simulated responses are derived from a model which presents the contractile response of the ileum both to added drugs and to transmural electrical stimulation. Simulated contractions of the gut are presented on a scrolling display comparable to that of a chart recorder. Students may take measurements directly from the monitor.